Gov't is going to try and break the big ones up, and stop M&A's as anti-trust sentiment warms up. Startups will become much, much harder to benefit from. The cost of capital is going to go up and make it harder to fund-raise, and people will get much more judicious about what they invest in. If your company isn't tied to some other industry or sector of the economy and is a tech company, just consider if your business can survive on its own for the next 3 - 5 years.