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Re:What can mRNA treat next? by 8note on Monday May 03, 2021 @01:11PM (#27027741)
You could maybe skip the cell death part, and instead trigger some existing telemetry systems that the immune system already watches for?

At least then if something goes wrong, you could still be put on immunosupressants

Re:What can mRNA treat next? by elcritch on Monday May 03, 2021 @05:09PM (#27030677)
From what I’ve read both are options. There’s benefits to getting the immune system to target cancerous cells Such as ongoing protection. Directly killing the cells is a good way to reduce tumor mass by direct injection however. The first t-cell immune treatments almost killed the patients due to liver/kidney overload from cellular debris as the immune system reacted too strongly, so being able to in cull tumor mass in a controlled fashion likely has merit as well. Either way the “detection method” would need to be very well tested and robust I imagine. Though the first treatments could be for “last chance” treatments that’d enable testing the safety of the particular detection method.