SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by Alex3917 on Sunday May 02, 2021 @11:08AM (#27015923)

Yeah we've known this for over 10 years, zero surprise here. There were literally popular books written saying that this would be the mechanism of action for novel coronavirus pandemics (and how to treat them) years before the current pandemic even started, e.g.:

https://www.amazon.com/Herbal-Antivirals-Remedies-Resistant-...

Here is the direct quote from the book, published in 2013:

"Once receptors on these cells are compromised there is enhanced vascular permeability, increased lung edema, neutrophil accumulation, and worsened lung function. In essence, once the virus begins attaching to ACE-2, ACE-2 function begins to be destroyed. ACE-2 function also tends to be less dynamic as people grow older, hence the more negative the effects of SARS infection on the elderly. [...] ACE (in contrast with ACE-2) inhibitors increase the presence of ACE-2 and help protect the lungs from injury."

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by dctoedt on Sunday May 02, 2021 @01:13PM (#27016905)

Not my field (I can spell DNA) but this recent piece seemed of interest. FTA: "A large meta-analysis provides yet more evidence that ACE inhibitors and angiotensin receptor blockers (ARBs) pose no harm to patients with COVID-19 and may even be associated with protective benefits, particularly in patients with hypertension."

https://www.tctmd.com/news/continue-ace-inhibitorsarbs-covid...

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by Alex3917 on Sunday May 02, 2021 @01:47PM (#27017210)

Also women and smokers are underrepresented among hospitalized patients, which was the first confirmatory evidence from over a year ago.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by piva00 on Sunday May 02, 2021 @02:44PM (#27017725)

I know nothing about physiology (apart from up to high school level, so... Nothing), could you expand on how smokers and women relate to ACE-2?

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by sudosysgen on Sunday May 02, 2021 @07:40PM (#27020092)

Nicotine upregulates ACE2 expression, but I don't know about women.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by Blackthorn on Sunday May 02, 2021 @11:18AM (#27016002)

Yes, that's why they went looking to verify that hypothesis and lay out the mechanism that the virus acts...

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by justicezyx on Sunday May 02, 2021 @12:39PM (#27016603)

Is this Amazon book on herbal effects real? I am pretty familiar with Chinese traditional medicine, but their effectiveness is very dubious.

The author does not look like a medical professional either.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by jpxw on Sunday May 02, 2021 @12:48PM (#27016675)

It’s unscientific nonsense, don’t waste your time.

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Re:SARS-CoV-2 Spike Protein Impairs Endothelial Function via... by darkhorn on Sunday May 02, 2021 @02:27PM (#27017570)

So, some people were studying new kinds of viruses?

Oh, okay, yeah, here https://www.wired.com/2013/05/h5n1-h1n1-reassortment/

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