* Ripple editing (Alt-P, once to enable for one track, twice to enable for all tracks - keeps stuff in sync, prevents gaps)
* Auto crossfade (enabled by default; just split a clip with by hitting "S" and drag one part on top of the other to create a smoothly editable fade)
* Jump to transient (Tab/Shift-Tab for next/previous, Ctrl-Tab for nearest)
* Peaks: Toggle spectrogram and peaks (this one doesn't have a shortcut, but you can find it in the actions palette that opens when you hit "?")
First, during your recording session, record a track with no performance at all, just the mic in the location that you'll be recording, with no noise gate. I usually record about 5 minutes of that and then loop it to create a track. Having this room sound in the background of the track means that if you split out a word or sound from the performance track, there won't be a discontinuity in the ambient room sound.
I also use the Markers feature in Reaper heavily- the first time I listen back to the performance, I'll add markers wherever I hear a mouth noise, click, or an umm/uhh which sounds awkward. If nothing else, I can look at the markers and get an idea of how much work there is to do, and having the markers makes it easy to move the cursor to the next edit.
For the actual edits, I typically just zoom in on the region around the sound, use the keyboard split shortcut to split the region, and then hit the shortcut for toggle item mute for the item with the word. Reaper has an option to automatically crossfade items on split, which I have enabled, and I can drag the volume envelope to keep the previous word from getting chopped too sharply.
I've been using the Izotope Declick/Denoise plugin, which is inexpensive and seems to work pretty well. I suspect that there are some things I could be doing to dramatically speed up the process I mentioned above- fortunately youtube is loaded with Reaper tutorials for this sort of thing, and I look forward to learning some new tricks!
Jumpcut editing - popular amongst some of the youtube crowd - can be way more frustrating for some consumers than hearing a person periodically pause with an uhm / ahh, or insert the word 'like' several times a sentence, or start every sentence with 'So...'.