42% Lower Risk for Dementia Following Adult (Tdap) Vaccination

Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by skybrian on Saturday April 24, 2021 @12:45AM (#26922311)

I don't see a way to access the article itself. From the abstract, it sounds like this isn't describing a randomized controlled trial, but rather a study based on database searches of VHA and Marketscan data?

Controls are mentioned, but I wonder if it's possible to correct for the reasons people might decide to get a shot.

Kaiser's recommendation: "Get a tetanus shot as soon as possible if you have a dirty cut or wound and 5 or more years have passed since your last tetanus shot." [1] (Emphasis added.)

This would tend to select for people who do more outdoor activity and are in better shape.

It sounds like doing an actual trial could be interesting, though.

[1] https://healthy.kaiserpermanente.org/northern-california/hea...

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Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by aaomidi on Saturday April 24, 2021 @11:22AM (#26925517)

Actual article https://watermark.silverchair.com/glab115.pdf?token=AQECAHi2...

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Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by nkurz on Saturday April 24, 2021 @11:57AM (#26925869)

I appreciate the attempt, but your link unfortunately already gives an error message: "Your session has timed out. Please go back to the article page and click the PDF link again."

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Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by LatteLazy on Saturday April 24, 2021 @05:32AM (#26923569)

It would also select for health conscious people with at least a little disposal income

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Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by withinboredom on Saturday April 24, 2021 @06:33AM (#26923834)

The VA is completely free for vets (at least for me).

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Re:42% Lower Risk for Dementia Following Adult (Tdap) Vaccin... by tom_mellior on Saturday April 24, 2021 @04:58AM (#26923438)

> Get a tetanus shot as soon as possible if you have a dirty cut

If you were to go for that, would they be giving you a tetanus-only shot or a combined TDP shot? That might be a significant difference that the paper should have explored.

At least in the few European countries I know of, I believe TDP is something we get by default as part of the many childhood vaccinations. Though I do believe most adults stop getting the regular boosters. In this context, I don't know how to interpret the article's "Patients either had or did not have a Tdap vaccination by the start of either of two index periods" -- what group would you be in if you had it 50 years ago? What exactly is an "adult vaccination", and does it matter if you were vaccinated as an adult but it was 30 years ago?

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