There are consequences to the proportion of some nucleotides, the most well-known being the GC-content[1], or proportion in a sequence of bases being G or C (G pairs with C and A pairs with T). There are benefits to a higher GC-content, like the sequence being more stable.
From this the obvious question would be why this matters, since you obviously can't replace an A-T pair with a G-C pair just to increase this proportion. Except that there are ways to do it… kind of. If you look at the codon table[2], you'll see that there are multiple ways to represent each protein encoded by a triplet of nucleotides.
I love how the DNA language, much unlike spoke words, is in close relation to physical properties of the world.
There really is some exciting magic in the interception of biology and computation.
It can still be used to find a substring of 100 64-bit values in a much longer 64-bit string, but ... it’s a problem I never encountered (and only encountered a 16-bit version of it once in my life). Then again, if you use 32-bit for each Unicode character and have a lot of emojis, it might still be somewhat competitive with brute force.