Association of sleep duration in middle and old age with incidence of dementia

Re:Association of sleep duration in middle and old age with ... by jiofih on Thursday April 22, 2021 @05:23AM (#26900595)

Well, they are found in everything, meat, soy sauce, beer, right? Tobacco is a much more common source. By the logic of your previous argument, eating yakisoba could lead to dementia.

Interestingly, your source’s paper on this says that coffee protects against brain disease:

> epidemiological studies have consistently shown that coffee drinkers have an apparently lower incidence of Parkinson's disease (PD), suggesting that coffee might somehow act as a purported neuroprotectant

https://pubmed.ncbi.nlm.nih.gov/16139309/

Either way, I’m not particularly interested in this subject, the point is that making wild medical claims without sources in an online forum is best avoided.

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Re:Association of sleep duration in middle and old age with ... by eurasiantiger on Thursday April 22, 2021 @08:50AM (#26902149)

They are indeed found in many products, but the key is the exact nature of the specific substances. Do they inhibit MAO-A, MAO-B, or both? Are they irreversible or reversible inhibitors? Do they do other things like cause neurotoxicity? The Harmala family has dozens of compounds, some good for you (for example MAO-B inhibitors indeed prevent PD, because MAO-B inhibitors are used to treat it) and some bad, like some beta-carbolines that are indeed neurotoxic.

Again, the total amounts are what matters. It’s much easier to take in too much MAOIs from tobacco and coffee than by eating meat.

Something seeming to protect against one specific disorder does not mean that it protects against all diseases.

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