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A comment on Inflammation, but Not Telomere Length, Predicts Ageing at Extreme Old Age.

Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by kgin on Friday April 16, 2021 @11:05PM (#26841294)
Epigenetic clocks measuring methylation sites across DNA are currently the most accurate way to measure aging https://en.wikipedia.org/wiki/Epigenetic_clock

What's more, it seems that it is possible to reset the epigenetic of cells to their youthful state and reverse actual the biological age of those cells. They don't just "measure younger", they function as they did when they were younger. https://www.nature.com/articles/s41586-020-2975-4

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Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by perl4ever on Friday April 16, 2021 @11:19PM (#26841343)
>currently the most accurate way to measure aging

I don't understand what people mean by statements like this. Per the Wiki page, they found something that on average is highly correlated to chronological age.

But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise? What is the reference point for the "real" age that is not chronological age?

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Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by chub500 on Saturday April 17, 2021 @07:52AM (#26843568)
I just watched an interesting Veritasium on this aspect of aging: https://m.youtube.com/watch?v=QRt7LjqJ45k
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Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by fao_ on Friday April 16, 2021 @11:21PM (#26841355)
> But in individual cases, it may be off a little or a lot. What tells you this is meaningful information and not random noise?

Because it was more accurate than other data sources we've tried

[ Parent | on HN ]
Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by perl4ever on Saturday April 17, 2021 @11:14AM (#26844843)
It appears to me to be "more accurate" because they have defined the discrepancies as more accurate. Why not just define them as inaccuracy?
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Re:Inflammation, but Not Telomere Length, Predicts Ageing at... by jaygernaught on Saturday April 17, 2021 @03:59AM (#26842462)
interesting, what are your thoughts on modifying our epigenetics via crisper to pulse Yamanaka factors? also what ever happened to that CEO who gave her immune system a boost with stem cells?
[ Parent | on HN ]