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Re:Psilocybin 'promising' for depression by hervature on Thursday April 15, 2021 @03:13AM (#26817074)
This is why research is needed. My gut feeling is that the root cause is overdosing. Just search "How often can I do shrooms" on Quora and you get the gamut from "1 or 2 times per year", to "microdosing everyday, macrodose every weekend, and hero dose every month".
Re:Psilocybin 'promising' for depression by high_priest on Thursday April 15, 2021 @10:33AM (#26820999)
This is why, even though I stand firm behind the fact, that psychedelic experiences changed my life, I stay sceptic about changing body/brain chemistry over longer periods of time.

I used to macrodose and get immensely creative over a week or so. With a happy outlook on nature and all things uncontrollable around me.

But then the high died some day. Lethargy came back. Lack of actual structure and the 'happy go lucky' attitude derailed whatever tied my past with plans for the future.

Microdosing seemed to help from time to time, but mostly I just get distracted with random consumption instead of planned, structured and thought through creation.