Yep. For example, here is Fill's GIFs site[0], where comic animation on pages represented as video instead of GIF.[1]

    ...
    <video autoplay="" loop="" muted="">
      <source src="/video/aa3d713c20ba03cc3f87b36e9a947857.mp4" type="video/mp4">
    </video>
    ...

[0] https://fill.com.ua/

[1] https://fill.com.ua/gif/zagostrennya