Re:Against Alcohol
by heavyset_go on Saturday April 10, 2021 @07:30PM
(#26766272)
Naloxone isn't orally active, so it isn't actually inhibiting anything for people who aren't abusing it. The opioid blocking effect comes from buprenorphine itself, as it is a partial agonist with a high binding affinity. It binds preferentially to the mu-opioid receptor compared to many opioids, and as a partial agonist, it has a weaker effect than some other opioids.
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