Depends on what you actually want to do, because Photoshop is an all-trick-three-legged-pony, whereas the alternatives are all "we need to do X, and we need to do it well, let's actually make that application instead of something as insane as Photoshop".

Krita, Clip Studio Paint, DxO, aseprite, there are tons of great options if you actually want an application that was written to be "what people who want to do X want in an application", instead of trying to be all things to all users.