Rhesus Macaques [0] have a lifespan of thirty years. Thirty years. Thirty years in a massively controlled environment, often sedentary, with limited opportunities to socialise with peers, and the simple pleasures of mutual grooming, lying in the sun etc. Lab animals that are rehomed in rehab centres / zoos etc are often overweight, in poor health, and have a range of nervous tics and social inexperience. Many adapt to the non-lab environment, but they tend to have underlying health problems and issues with acceptance by the alpha individuals because they lack the years of experience required to understand and fit into the complex group etiquette.

Animals may still be the best model for testing drugs / devices that will go into humans, but lets not understate the massive cost to the individual animals concerned.

[Source: personal involvement with a primate rehab centre]

[0] https://animalia.bio/rhesus-macaque