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A comment on FDA approves first test of CRISPR for genetic defect causing sickle cell disease. Parent comment

Re:FDA approves first test of CRISPR for genetic defect caus... by rcthompson on Thursday April 08, 2021 @08:02AM (#26737687)
Yes, but T-cells learn to distinguish self from non-self in the thymus, and I don't believe this treatment alters the hemoglobin gene sequence in the thymal epithelial cells. Of course, the thymus, like the rest of the body, will be served by red blood cells containing the new hemoglobin gene, but I'm not sure if this alone is sufficient for immature T-cells in the thymus to learn it as a self protein.
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Re:FDA approves first test of CRISPR for genetic defect caus... by tibbydudeza on Friday April 09, 2021 @08:19AM (#26749573)
My understanding is that the "fixed" red blood cells antigens would be the same so the T-cell would not be triggered.
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Re:FDA approves first test of CRISPR for genetic defect caus... by rcthompson on Tuesday April 13, 2021 @10:12PM (#26802211)
All the antigens would be identical except those derived from the modified gene. This tiny difference probably is pretty likely to escape detection, but not 100% guaranteed.
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