It depends , I think some mods might be now onlyu updated for SE , some will also suggest S# because is more stable (on Windows). I think I am not qualified to give a correct answer. I have both installed and setup, it was not easy and I gave up on graphics mods (emb or shaders that come with .dll files).

Now I started maybe 1 year ago a new game on SE, just essential mods for me because I had the bad luck of my game crashing in certain regions of the map when I was around level 30 and I had to give up on the save. I was using those cool mods that improve the cities with new buildings, NPCs and quest. I could not solve that issue and I promised myself that I will play next time only with minimum stuff.

I suggest to ask in winegaming subreddit for more info on what other players are using and what to avoid. If you have both games try them both , no mods and compare how it looks and feels.