Re:Moderna mRNA sequence released to GitHub [pdf]
by shellfishgene on Tuesday March 30, 2021 @06:42AM
(#26633045)
Generally I agree, but it could be the case that the modified bases work just well enough for tRNA matching in the ribosome, but not with the reverse transcriptase.
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Re:Moderna mRNA sequence released to GitHub [pdf]
by flobosg on Tuesday March 30, 2021 @06:50AM
(#26633092)
The mechanism of base complementarity is identical in both cases. If a modified uracil complements an adenine in tRNA, it will complement an adenine in the RT primer or an adenine being added to it.