The terrain along the Negev route is extremely hostile. Bypass proposals have mostly focused on rail lines from Eilat/Aqaba to the large and well-developed Israeli ports on the Mediterranean, but even constructing rail lines there is quite difficult.

An underappreciated fact of Israeli and Palestinian geography is its mountains and hills; any major transportation project [1] requires extensive tunnel and bridge work.

[1] Examples: the TLV/Jerusalem high speed rail, the Haifa highway bypass, or a proposed transportation corridor connecting the main West Bank population centers along the ridge of the Judean and Samarian mountain ranges.