> Are we really at a point where a pronoun is persecuting people...?

If you're intentionally going out of your way to use a pronoun that someone doesn't feel represents them, then yes - that is persecuting them.

If someone asks you to stop, and you keep doing it - that's persecuting them.

> Are we really at a point where a pronoun is persecuting people

Chosing to reject someone's identity is persecuting them, yes. Luckily in England the courts agree and transphobes who refuse to use people's correct pronouns often lose their employment tribunal cases.

“Often” - I’d be curious to see stats. Not that I don’t believe you, I do; I’m just thinking this is such an edge case of an edge case, that the trade-offs involved in accommodating it might not be worth for society at large. After all, the Holy Inquisition made ultracatholics very happy too.

It's actually a hate crime in Canada. You deliberately misgender someone, you can expect to be arrested and maybe spend time in prison.