That depends. Often enough, regulatory burden tends to scale with size as well! But I agree that quite a lot of compliance requirements apply to everyone, and that they're much harder for small companies to meet.

However, the reason for those requirements isn't, ostensibly, to make disruption difficult - it's to protect the society from problems that can be caused by companies of all sizes equally easily. For example, safety regulations about medical equipment. Or data protection regulations. To the extent these laws make disruption difficult, it's often unfortunate cost of safety.

(I understand though that the real world isn't perfect and big players tend to influence these laws to their benefit. But perfect being the enemy of good, and all that.)