The EMA Covid-19 data leak, and what it tells us about mRNA instability

Re:The EMA Covid-19 data leak, and what it tells us about mR... by Izkata on Tuesday March 16, 2021 @04:33PM (#26482515)

mRNA encodes instructions for creating proteins, and prions are mis-folded proteins. I think the concern is more, our bodies' natural mRNA is unlikely to create prions or it would be a common occurrence, but lab-created mRNA isn't made of the same parts and doesn't have that millennia of evidence behind it.

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by maxerickson on Tuesday March 16, 2021 @04:38PM (#26482586)

This lab created mRNA creates a protein from a highly infectious virus, so it's probably not a big additional risk over the medium term (body probably gonna be folding some of them either by vaccination or infection).

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by wrycoder on Tuesday March 16, 2021 @05:06PM (#26482978)

Prions are mis-folded proteins which cause a cascade of mis-folding in proteins of the same structure which are already present in the body. The mis-folding affects their biological activity.

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by fennecfoxen on Tuesday March 16, 2021 @10:06PM (#26485674)

The “proteins of the same structure” we are talking about here are virus spike proteins. Assuming that there is a pathway that leads to the misfolded form propagating to begin with, the damage is that other spike proteins don’t work. These proteins, however, were never intended to perform any function whatsoever.

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Re:The EMA Covid-19 data leak, and what it tells us about mR... by urspx on Friday March 19, 2021 @01:15PM (#26515851)

It was posted here before, but you can look at an analysis of the mRNA source code of the Biontech vaccine here: https://berthub.eu/articles/posts/reverse-engineering-source...

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