Re:The tragic history of the only diet pill that worked
by philipkglass on Tuesday March 02, 2021 @08:50PM
(#26323732)
You might wonder how "a shady outfit called Isabella Laboratories" discovered the only diet pill that worked. They were just commercializing, recklessly, others' research. This 1933 JAMA article told the world about 2,4 DNP's striking effects:
"Actions And Uses Of Dinitrophenol: Promising Metabolic Applications"
2,4 DNP was being scrutinized due to its poisoning of explosives workers during the First World War.
The whole paper is worth reading. The benefit and great danger of the compound are stated very succinctly:
"When dinitrophenol is given to experimental animals, it causes an increase in metabolism within one minute after injection, or somewhat more slowly, when given gastrically. The increase in metabolism with doses of 10 mg per kilogram or less is about 50 percent. With higher doses, metabolism may be increased fourfold or more, until the animal produces heat so fast that it may be killed by the resulting fever."
"Actions And Uses Of Dinitrophenol: Promising Metabolic Applications"
https://jamanetwork.com/journals/jama/article-abstract/24402...
https://sci-hub.se/10.1001/jama.1933.02740280013006
2,4 DNP was being scrutinized due to its poisoning of explosives workers during the First World War.
The whole paper is worth reading. The benefit and great danger of the compound are stated very succinctly:
"When dinitrophenol is given to experimental animals, it causes an increase in metabolism within one minute after injection, or somewhat more slowly, when given gastrically. The increase in metabolism with doses of 10 mg per kilogram or less is about 50 percent. With higher doses, metabolism may be increased fourfold or more, until the animal produces heat so fast that it may be killed by the resulting fever."