No I just don't like having to stop what I'm doing, get up, go into another room or my backpack, and fetch a yubikey, interrupting my focus for 30-90 seconds. I have enough trouble getting and staying focused without additional interruptions.

I have like 4 laptops and two main desktops and if I didn't have 4 yubikeys in them then this would be a multiple-times-daily occurrence. Yubikeys aren't that expensive, and I mostly use the usb-c "nano" ones which are designed to live 24/7 in a computer's port, only sticking out about 2-3mm. Sometimes I have to move them around to other temporary machines but for the most part having approximately the same number of keys and computer workstations means that this is pretty infrequent.

I even have two Davinci Resolve Studio activation dongles for this same reason, and I can't physically edit video on two different computers at once, one would do if I were willing to keep track of where it is and shuffle it around between my various machines as needed.

It's pure speed/convenience, not a response to some data threat.