I think most Americans are doing just fine with high fructose diets. However, there have been a lot of studies coming out, that seem to be suggesting there is some danger of obesity after a certain low carbohydrate diet or skipping carbohydrates altogether, as these diets tend to spike blood sugar rapidly. The most interesting is a study in humans, that showed a significant increase in blood glucose when carbohydrates were restricted . However, the more I look at it the more I feel like the results are definitely not true for me. I still get a pretty nice feeling in my mouth after eating sugar but I don't notice much of a difference in taste, taste just seems dull, bland, sour, and nothing much else, other than I don't feel I need as many carbohydrates as I did before.