MDMA I'm less sure about due to possible neurotoxicity, I'd need to do more research on it, but my mind isn't closed to it.
I expect it will be a powerful tool that can help people suffering from a wide variety of traumas. Side note, but we don’t understand nearly enough about trauma. Unresolved trauma is an enormous driver of human suffering. I think it may far more widespread and take many more forms than what the textbooks say.
Relatedly, maybe humans had better ways of coping with trauma in the past, through communal bonds, more strongly shared world views, rituals, and so on.
Occasional use is very different from the "wake and bake" style of using marijuana every hour or so. I fell into the former category, as did some friends of mine, but I knew many who were in the latter. The differences a few years on are quite profound.
Marijuana usage as a child or teenager is significantly correlated with declines in IQ by adulthood. Whether it's causal is up for debate, but avoiding it as a teenager is a good idea given extant knowledge.