He was subjected to house arrest for advocating for a "new" idea. We now accept heliocentrism as the correct answer. It's not terribly important to me if it was, in fact, his idea...etc. etc. He's the best known example of "scientist says something we now currently accept as scientific fact -- and there is hell to pay for him during his lifetime."
W.r.t. Semmelweis, I don't know how this played out,
He was a physician in charge of two clinics who had studies backing up his "crazy" idea that physicians should properly sterilize their hands before delivering babies if they wanted to reduce mortality rates. He was essentially driven crazy, thrown in an insane asylum and beaten to death by the guards in short order.
I view it in simpler terms as "He was effectively murdered." because although he had studies, he had no explanation for how and why, so it was rejected out of hand.
This was maybe two decades or so before we accepted germ theory and modern sterilization techniques for surgeries and so on.
W.r.t. Semmelweis, I don't know how this played out, so you'll have to fill me in. I would make an initial distinction, though. The first is that once a theory achieves widespread acceptance, it's not surprising that honest people will be slow to absorb something that they can't account for. It takes time to process evidence. Think how absurd it would be to just throw away something that's made sense up until now. You have to reconcile new observations and do the work of accounting for everything accounted for by the previous theory plus the new thing. Throwing it away just like that leaves you with nothing to work with. The second distinction is that a lot of people build their egos out of knowing something and the feeling of dominance they get from it. "I'm hot shit and superior to you because I know X." Then you get these little cliques and cults of affirmation which adds another barrier because now you face the Lomanesque risk of no longer being liked.The coward cannot bear that possibility so he "defends" his tribe to protect himself. Of course, he isn't really acting for his own good or the good of others, just his own comfort.
But in general, yes, academic fads and prejudices do exist. Try being a conservative at a major university today, especially in a humanities department.