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Re:California State Legislator Introduces Bill to Decriminal... by PragmaticPulp on Thursday February 18, 2021 @07:28PM (#26187840)
> and there has been legitimate investigation into their benefits.

I'm pro-legalization and all for rigorous study of these compounds. That said, the recent headlines about psychedelic research have started to diverge from what the research actually says.

For example, recent headlines claimed that MDMA was shown to be beneficial for certain types of therapy. However, the actually study wasn't designed to show if MDMA was helpful, it was only designed as a proof of concept to show that it wasn't harmful. The study protocol involved something like 20 therapy sessions, only 2 of which involved MDMA. Most of the measured benefit happened before any patients took any MDMA at all, and the data didn't show any measured boost around the MDMA sessions. They also gave MDMA to every study participant instead of only half, meaning it was impossible to determine if the MDMA made a difference relative to non-MDMA controls.

The only thing they really measured was that MDMA didn't produce any immediately obvious problems, such as causing patients to withdraw from the program. Safety studies like this are an important first step, but they don't tell us if MDMA is actually helpful.

However, all of the headlines around the study proclaimed "MDMA shown to help treat PTSD". All of the internet comment sections were filled with people wondering if they should take MDMA to treat their PTSD. Really, the only thing the study showed was that traditional therapy produces measurable improvements in the condition, and that MDMA didn't interrupt those improvements.

I'm worried that the exuberance to paint psychedelic drugs as miracle cures is going to backfire in a few years if the eventual study data doesn't live up to the hype.

Re:California State Legislator Introduces Bill to Decriminal... by gvhst on Thursday February 18, 2021 @09:01PM (#26188601)
I'm confused... Are you saying the ongoing MAPS FDA Phase 3 trials [0] are more about safety than efficacy? The whole point of Phase 3 trials is to prove efficacy.

Additionally, earlier studies [1] measured the participant's CAPS (Clinician Administered PTSD Scale) pre and post treatment which showed pretty significant results.

[0] https://maps.org/research/mdma/ptsd/phase3/timeline [1] https://maps.org/news/media/7538-reason-ptsd-study-finds-dra...

Re:California State Legislator Introduces Bill to Decriminal... by sep_field on Thursday February 18, 2021 @07:35PM (#26187902)
There have been a -lot- [0] of MDMA studies at this point, for PTSD and other issues. In particular a common finding is that the efficacy of MDMA+Therapy 1 year post-treatment is far higher than therapy alone (significant reduction in relapse of symptoms as well as severity of symptoms). I encourage you to look at the variety of studies conducted and their different designs and controls and not base your judgement on a single study (this is good advice for any medical research, not only MDMA, as well).

[0] https://maps.org/research/mdma

Re:California State Legislator Introduces Bill to Decriminal... by PragmaticPulp on Thursday February 18, 2021 @08:02PM (#26188127)
Yes, and I read them all as they come out, including the MAPS studies. My point still stands: The studies, to date, appear to be structured in ways that primarily explore the potential downsides rather than exploring relative efficacy. Not all of them, of course, but it is a common theme.