I also have a Topre keyboard, the Leopold FC660C, with a Hasu FC660C Controller supporting QMK firmware. The 12 keys closest to my non-pinky fingers are all tap/hold, so for example my hands don't move for control sequences. Alternate keymaps like Dvorak make sense if one needs to optimize letters for composing words. Shortening finger travel for programmers is an entirely different ball of wax, with many solutions involving QMK firmware.

I had bought or built various mechanical keyboards, before settling on Topre switches. Topre switches are an obsession killer; many people find them vastly superior to any mechanical switch, and the customization options are nonexistent. One can't post pretty pictures of one's newest keycap set; one has to focus on the QMK keymap.