Not saying you should, but it's entirely possible to have nodes all over the world managed by a single set of master nodes. The system is not really designed with that use case in mind though, the added latencies will hurt a lot in getting etcd consensus.

While it is certainly possible to have mixed region clusters, from my experience it is better to have one cluster per region. Do your synchronous communication within the cluster / within the datacenter with sub millisecond latencies and do asynchronous communication across cluster boundaries with up to triple digit millisecond latencies.