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Re:Guile – Scheme Implementation Supporting R5RS, R6RS, and ... by selfishgene on Monday February 08, 2021 @06:48PM (#26071977)
TeXmacs is an impressive project spanning several decades:

https://www.texmacs.org

It uses Guile as its scripting language and documents created within TeXmacs are represented as Scheme programs.

In addition to providing a LaTeX-quality WYSIWYG editor experience for scientific documents, TeXmacs can also be used as a computer algebra front-end for packages like Mathics, which provides an open-source implementation of the Wolfram programming language used in Mathematica:

https://mathics.org/

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