When I twist something I prefer to twist the top of my hands out, so I would twist something different if I was holding the tie with my left or right hand. So I absolutely believe that the handedness affects this because it will change which hand holds the bread and which holds the twist tie. If I hold the bread in the left (twist with my right) I would twist it clockwise (righty tighty) and if I held the bread in my right I would use my left and twist counter-clockwise.