https://en.m.wikipedia.org/wiki/Good_manufacturing_practice
Granted, more biohacking and bio experimentation is a good thing. Innovation should not be gatekept by institutions and the establishment.
Here's a startup idea for whoever's interested:
Take lab grade pharmaceutical drugs and turn them into human-rate drugs at a low cost.
https://www.bloomberg.com/news/articles/2020-10-10/home-made...
Neanderthal DNA has been linked to severe outcomes from COVID.[0] To me that means I'll get vaccinated (and strain specific boosters that may have to happen), full stop. But if I have a choice of more than one type of vaccine available at the same time (unlikely? But still), then I will try to keep this in mind. Other than that it just means I will be extra careful.
Disclaimer: not a scientist; and anything I say here is first-person (I'm in the demographic groups I'm referring to).
My non-scientific speculation: there is a chance the stuffy nose could be a proxy for high neanderthal DNA. I say that because other sinus and nasal issues are among the things linked to genes inherited from Neanderthals. They had different anatomies in that regard. I've read it could have been an adaptation to cold.
I've also read that the extinction of Neanderthals may have been related to viruses causing respiratory problems/diseases.[1]
Anyways, the point is, that some of these genes could correlate with severe outcomes from coronavirus.
If a reader knows their genetics, and/or knows people who have mentioned they have a relatively high amount of neanderthal DNA... You might want to think about it or mention it to them. Especially if they have other respiratory or sinus things going on.
[0]:
https://www.nature.com/articles/s41586-020-2818-3
https://www.sciencemag.org/news/2020/12/neanderthal-gene-fou...
[1]:
https://www.sciencedaily.com/releases/2019/09/190919080755.h...
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[btw I accidentally posted this comment to the wrong thread then moved it. Not trying to spam or rant, I'm just bad at commenting because I rarely comment. Anxiety and so on...]
This was an interesting comment. I don't think it is particularly likely that Neanderthal DNA is associated with more stuffy noses, but who knows! An interesting hypothesis for sure.
There's only one of you, no second chances if you mess up.
If it was July, and this post popped up, heck even November pre-US election when we were told the vaccine was months away, would that change the equation?
I feel like there are two questions here:
1. is this safe? If so, how safe?
2. Is it worth trying?
Question 1 is quantitative and verifiable, whereas question 2 is one of risk preference.
I am a little worried that https://radvac.org/vaccine/ mentions that their vaccine has "the most extreme complication in some recipients of stuffy noses." I would expect a functioning vaccine to elicit an immune response. I would be more comforted if, like the mRNA vaccine, a sizeable percentage of people trying the DIY vaccine developed a short fever. Though according to them this is expected: "Intranasal delivery of chitosan-based vaccines have shown mild side effects and high levels of efficacy of both mucosal and systemic immunity, when delivered in a prime-boost regimen (in both animal models and human trials). "