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Re:UCSF team has engineered a tiny antibody capable of neutr... by zepin on Wednesday February 03, 2021 @04:16AM (#26011947)
> and there are reasons why they're not part of any drugs

Caplacizumab (Cablivi®) is a Nanobody (2 VH units linked together) approved by the EMA since 2018 (and by the FDA since 2019).

Re:UCSF team has engineered a tiny antibody capable of neutr... by AstralStorm on Wednesday February 03, 2021 @07:35AM (#26013068)
Mind you this is used for TTP and thrombosis, where short lifetime is a benefit. You want to remove the clotting factor now, not forever. (We have drugs for that too.)
Re:UCSF team has engineered a tiny antibody capable of neutr... by est31 on Wednesday February 03, 2021 @08:16AM (#26013307)
Short lifetime can be a benefit for anti-Covid medication too. An antibody could cross react with a vaccine and hamper the immune system response, preventing it from launching a proper reaction and creating proper immunity. You don't want the person having to wait for weeks while being vulnerable until they can get a vaccine after a successful therapy with antibodies.

But of course, distribution is a headache.

Re:UCSF team has engineered a tiny antibody capable of neutr... by labawi on Sunday February 07, 2021 @05:24AM (#26054009)
A person having an an immune system that can be vaccinated with traditional vaccines (including mRNA), while not developing meaningful resistance (such that a second infection isn't serious even if possible) from an infection where they needed antibodies, doesn't seem very likely. And if they were treated with antibodies once, they could probably just use them again, so it doesn't seem important.

Nevertheless, it would still be moderately impractical in the sense that a vaccination immunity should (probably?¹) be more effective than immunity after an infection, but it may not properly develop until the vaccine is administered without (much) antibodies present.

¹ is there any evidence or a sound supported theory that a coronavirus vaccine is more effective and/or long lasting than immunity after an infection?

Re:UCSF team has engineered a tiny antibody capable of neutr... by ramraj07 on Wednesday February 03, 2021 @09:06AM (#26013666)
Touche, there do seem to be approvals. I'll edit my post.
Re:UCSF team has engineered a tiny antibody capable of neutr... by Cthulhu_ on Wednesday February 03, 2021 @04:38AM (#26012066)
One example of a very new drug; do you have any others? Any studies on its efficacy and side effects?
Re:UCSF team has engineered a tiny antibody capable of neutr... by FrojoS on Wednesday February 03, 2021 @06:04AM (#26012569)
It’s a bit unfair to ask the parent to do this legwork. The fact that it got approved implies that it is effective and that side effects are rare and/or relatively minor.

Edit:

From the phase II trial:

“ Adverse events overall were similar between groups, with the exception of bleeding, which occurred more often with the immunoglobulin treatment (54% versus 38%). The two participants who died were both in the placebo group.” https://www.medpagetoday.com/Cardiology/VenousThrombosis/561...