In F#, you cannot disable inlining of small functions. It does IL source code inlining, like copy-paste, not machine code inlining. That increases generated dll/exe size a lot for generics. And sometimes you do not want to do that because it's worse for performance. There is an issue for that: https://github.com/fsharp/fslang-suggestions/issues/838
In C#, the AggressiveInlining attribute works well, in predictable manner. Non-inlineable cases are well known (`throw\switch\fixed\try..catch\calling delegates` and some more https://github.com/dotnet/runtime/blob/master/src/coreclr/ji...).
> because it supports directly inlining IL instructions intermixed with regular code
This works for very simple things only. And using InlineIL.Fody, Sigil, raw IL.Emit or just raw IL code as text is not that more difficult if you already know IL.
> you _can_ write F# that's about as fast as non-unsafe C#
I tried this several times. It always ends with fighting the compiler more than just rewriting in C#, even without the `unsafe` keyword. In most cases due to generated IL that I cannot control from F#.
Also, most simple tail calls are rewritten by a compiler to a loop, but if you look at the generated IL, there are multiple temp variables, locals, needless assignments. Maybe JIT is able to eliminate those, or maybe not... In C# I could get IL that reflects what I write, without surprises.
This also means that a lot of F# functions that are not inlined by F# source-code inlining itself effectively have NoInlining attribute. E.g. some helper method `if x then y.call() else z.call()`, if not inlined by F#, will never be inlined by JIT due to .tail prefixes before the methods calls.
To be more specific, it has a C# library so it can use _unsafe {}_ blocks to perform manual memory management. This is one key performance-oriented feature that F# lacks.
Other than that, you _can_ write F# that's about as fast as non-unsafe C#, although it means giving up most of the nicer and safer features of F#. Use mutable structs and classes instead of immutable records, for/while loops instead of higher-order functions, magic values instead of option/result types, etc... I've done it in a couple of hot paths where it made sense, but quite reluctantly.
Inline functions are still fine though for writing zero-cost helpers, and I don't think C# has them (there's an <AggressiveInlining> attribute but IIRC it's just a hint, the compiler isn't required to actually obey).
Ironically, F# _could_ become the best language for high-performance .NET programming, because it supports directly inlining IL instructions intermixed with regular code (whereas C# has to go through the ILGenerator class). Unfortunately it's considered such a niche case that it's not planned to be expanded beyond the standard library, and to use it in your code you have to enable an undocumented / unsupported compiler flag.