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A comment on Johnson and Johnson single-shot vaccine appears 66% effective in global trial. Parent comment

Re:Johnson and Johnson single-shot vaccine appears 66% effec... by timr on Friday January 29, 2021 @08:28PM (#25965083)
There are a number of direct risks related to the Adenovirus itself. Multiple adenovirus vaccine programs have been scrapped over the years because of these issues:

https://cen.acs.org/pharmaceuticals/vaccines/Adenoviral-vect...

For example, famously, one Ad-based HIV vaccine was found to increase the chances of getting HIV. People still theorize that it might be due to the vector itself:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

(that said, these platforms are certainly better validated than the mRNA-based vaccines. There's an approved rabies virus vaccine based on adenovirus.)

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Re:Johnson and Johnson single-shot vaccine appears 66% effec... by angry_octet on Saturday January 30, 2021 @12:26AM (#25966440)
Yes other complications are possible, I had thought from the wording it was a concern about allergic reactions.
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