If I understand which board you're talking about (a thin hardboard on the back), I'm usually not worried about that one - I have a stockpile of nails available, and I could probably reinforce it with something I have on hand if the edges degrade too much. My problems are usually that driving screws and other fasteners sometimes damages the material, making the connection single-use only. It's fixable to some extent with adhesives, but once you start pouring glue down the shafts, the whole thing becomes that much harder to disassemble in the future.