I've been on a very layer/hold-tap heavy vertically staggered Iris for a long time, and a Let's Split before. Touching my macbook's internal keyboard just rewires me to its layout. The way bigger thing is when I use someone else's computer and they haven't mapped Caps-Lock to control or set up emacs option shortcuts, or space-cadet shift/parentheses. Those are all changes I've made to my internal keyboard so my muscle memory is there. The external keyboard is so different that it really doesn't affect it.