It takes me about a minute to recalibrate for a different keyboard, although I'm occasionally making typos for another 30-ish minutes (nothing tragic - most often happens when I reach for a somewhat rare key, like ~, `, =, +, etc).

So for me at least it's pretty quick. Having radically different keyboard layouts is actually helpful because it's really clear (to your muscle memory) that you're doing something very different.

I use the ErgoDox that I built from plans I found online, a MS Natural Ergonomic 4000, my laptop keyboard, and rectangular Dell keyboards for random computers at work.

If you've got the time/money and it looks interesting I'd encourage you to try it. If it works out you'll be happy, and if doesn't you'll at least know that it doesn't work for you. But hey, it's your choice, for sure :)