I am (or was - much now forgotten) "expert" at Latex/Tex, but recently have taken to using restructured text instead (more exactly, as a precursor to - the RST is used to generate Latex and then PDF). I don't know how it would work for mathematical formulae, but when you're free to use your own layout (ie not writing for some journal) it's pretty sweet.

For anyone interested, here's the source - http://code.google.com/p/pytyp/source/browse/pytyp.rst#23 - for this paper - http://www.acooke.org/pytyp.pdf - and here's some notes on how it was generated - http://www.acooke.org/cute/HowToWrite1.html

Even though Latex itself is usually not that intrusive, I find this significantly easier to read and write (particularly lists!) - it also feels more natural to edit the source (with Latex I switch more to the formatted result).