Re:Pfizer vaccine appears effective against mutation in new ...
by hobofan on Saturday January 09, 2021 @02:50AM
(#25698471)
Doesn't it change the dynamics insofar as that you have a straightforward path from virus -> its mRNA blueprint, without more specialized and likely costly engineering of e.g. a adenovirus? This should then allow for broader protection against viruses with many strains e.g. a HPV vaccine cocktail that protects against all ~100 known strains vs. just the 9 it currently does.
[ Parent
| on HN ]
Re:Pfizer vaccine appears effective against mutation in new ...
by raducu on Saturday January 09, 2021 @03:06AM
(#25698564)
Some influenza antibodies destroy certain neurons in your brain and you develop narcolepsy.
This is both true for natural infection and first generation vacines.
Later generation vaccines avoid this by not presenting certain proteins.
My point is, you can't just include hundreds of protein variants without a lot of trials.
Re:Pfizer vaccine appears effective against mutation in new ...
by hobofan on Saturday January 09, 2021 @03:31AM
(#25698649)
I'm not suggesting to include new strains on the fly while they are discovered without trials. The same way they had to do trials for Gardasil-9 after already having Gardasil, they could do the same just with a wider cocktail.
In the optimal case you would attempt the 100+ cocktail and don't have any unreasonable side effects from them. Of course if there is a single variant in there that causes side effects you would need a ton of trials to triangulate which one causes them, but there is no guarantee that that is necessary or that you wouldn't run into that variant when you just adding 5 new variants in an iteration.