via https://adf.org.au/drug-facts/ayahuasca/
I imagine what Doblin meant is working with MDMA after an ayahuasca ceremony.
I also happen to be taking a dopamine agonist to treat a benign brain tumour I have (prolactinoma) - first line of treatment is adding a dopamine agonist to the system, and not using an SSRI/SNRI/etc that changes the actual function was fine as well for ceremony; a caveat to research or understand/have caution with is that I had done 30+ Ayahuasca ceremonies prior to taking a dopamine agonist - and so my mind/brain was generally already "opened" how it will be. Care/caution may be necessary if a person has never "opened" up their mind/brain yet (after X ceremonies/experiences) and if they are taking dopamine for whatever reason, as maybe once the pathways that get opened from Ayahuasca et al then the impact of the dopamine would shift as well - perhaps then overcompensating for blocks that get cleared by the Aya etc - and the person may then experience undesired levels of effects from the dopamine.
MDMA isn't directly changing the actual function, they're not causing inhibition; the action of how is important, the nuance is important to understand - though like from your comment - there isn't this general understanding that there is a difference, and I imagine most doctors/professionals will jump to the same conclusion without thinking about it - misattributing the different actions instead of critical thinking from foundational principles. It's not the neurotransmitter(s) that are a problem, at least not serotonin and dopamine, it's if the function change of how they're allowed to flow changes that's the problem.
Interview/chat between Dr. K (Healthygamer_gg) and Rick Doblin - https://www.youtube.com/watch?v=1e2h-awLC-s - where he mentions taking half-therapeutic dose; more of a casual conversation where you can also hear a bit of Rick's origin story.
I did fairly deep research on this beforehand, looking into actual pharmacological aspect of interactions with things like dopamine, etc - a few people over the last 20 years have been keeping track of all related research. I don't have the link for the most succinct, detailed writeup I read handy.
While you can read about mechanisms and in vitro this and that all day, this is not the same as quality applied clinical research, which frankly just doesn't exist in any meaningful quantity. I am a practitioner, and I am very sympathetic to the movement of alternative treatments counter to established standards of care, however at the end of the day it doesn't change the fact that the controlled research is non-existent or poor, and things like the MAPS manual are essentially woo.
And specifically the problems I have is that ironically, these alternative treatments which are supposedly trying to overcome boundaries of established care are extremely proscriptive themselves.. they're limited, just differently, and the justifications have very little evidence based backing.
Many studies have been done, not just in vitro but in real people with just about the most severe mental issues there are: severe depression and PTSD, and the results have been positive, and these studies have been published in peer reviewed journals and been well received by the scientific and medical community.
So can you describe what evidence you're looking for and what would satisfy you?
Also, you say you're a practitioner. I wonder what you are a practitioner of exactly. If it's some sort of traditional therapy you should be aware that for PTSD and severe depression the evidence is that traditional therapy is very ineffective. So what would you suggest for those suffering from these conditions if not psychedelic-assisted therapy, which from my reading is actually far more effective for these conditions than traditional therapy?
I’ve also sat a comparable amount of ceremony — and so of course there’s strictness about SSRIs...but I have never thought about the mechanisms like this. It just wouldn’t have occurred to me to explore in this way.
If you do find the succinct, detailed write up I’d love to see. Thank you for finding the YouTube link, I want to check it out!
The restlessness and agitation you're speaking of is often why people go dancing as when taking it primarily for recreational purposes, as it can have therapeutic effect as well; it can release energy that you need to do something with.
Doses between 60 and 100 mg of crystal that I have tested with Marquis reagent to be MDMA, as accurate as that test can be (there's no substance testing available for public in my country).
I had read beforehand that the comeup can feel uncomfortable especially right before the full effect hits. During my first experience I was kind of surprised how restless and annoyed I became at everything and I attributed it to not being able to be alone (I'm an introvert). On subsequent experiences alone I have come to realize that it's just part of the comeup for me and now I know to just ride it out. I read somewhere that MDMA triggers the release of norepinephrine which would make sense. One of my friends also commented that during comeup he too gets quite annoyed, to the point of ready to fight someone.
Basing on my experiences, the long comeup and the additional agitation is why I find it surprising to recommend MDMA for psychedelic crises. A benzodiazepine like Xanax has a quick onset of action and calms people down which makes more sense to me for these kinds of situations.
Arguably this is where mainstream medicine needs to catch up, and where a lack of multi-disciplinary approach still exists: Rick Doblin (the founder of Maps.org) has suggested that if someone has difficulty processing during an Ayahuasca ceremony (a potentially more intense, more potent version of Psilocybin session/ceremony) said to give a half-therapeutic dose of MDMA (100mg to 125mg is therapeutic dose; 180-200mg is generally what's used recreationally, usually not all at once) - and so I hope sooner than later this guide is updated to replace "possible administration of benzodiazepine or antipsychotic medication" with "possible administration of MDMA;" instead of numbing a person's nervous system/emotions with a benzodiazepine or changing how their brain is actually functioning, instead use MDMA to cause the brain to release more serotonin at once than it naturally can - allowing everything to feel and be easier to connect to and process; reducing the stress level enough where it's not acting as a blocking function, hence PTSD is from extremely stressful past experiences that are too overwhelming to process.