If you have valid reasons to make the move from Excel to Python, why not consider Julia? Environment is easier to manage (Pkg.add), the language "looks like Python and walks like C", math-friendly style possible, just-ahead-of-time compilation resulting in high performance (enough to not need native code implementations), interactive development (Jupyter was named for Julia-Python-R after all), @memoize may be enough for you and Pluto gives you reactive notebooks.

Bonus - tools are also emerging to make stand alone distributables.

Disclaimer: I neither work for nor am I affiliated with Julialang. I just use it.