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A comment on Messengers of hope: two mRNA Covid-19 vaccines herald a new era for vaccinology. Parent comment

Re:Messengers of hope: two mRNA Covid-19 vaccines herald a n... by arrosenberg on Wednesday December 30, 2020 @12:21AM (#25578847)
It's definitely not 1:1, but the mRNA degrades fairly quickly at body temperature (thus, 2 doses).

Here is a study of the effects - https://www.nejm.org/doi/full/10.1056/NEJMoa2024671.

It doesn't directly address your question, but it does show how the vaccine performs to control (labeled pbs) in terms of viral load and immune system activity when challenged with a dose of the virus.

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Re:Messengers of hope: two mRNA Covid-19 vaccines herald a n... by shellfishgene on Wednesday December 30, 2020 @05:07AM (#25580323)
The mRNA produced for the vaccines have various modifications that cause greater stability than normal mRNA.

The two shots have nothing to do with mRNA stability, they improve immunity, as in any other vaccine given in two or three shots.

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