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A comment on Raspberry Pi PCIe Devices. Parent comment
Power. PCIe is a fairly power hungry link. On-die parallel connections are incomparably more efficient.
Special low power links like MIPI PHYs also have their place.
USB is high enough speed that you will get quite a bit of overhead from USB>PCI>memory route, and back.
Audio is a particular pita, network too needs as close, and direct as possible connection to the CPU to get maximum performance.
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Power. PCIe is a fairly power hungry link. On-die parallel connections are incomparably more efficient.
Special low power links like MIPI PHYs also have their place.
USB is high enough speed that you will get quite a bit of overhead from USB>PCI>memory route, and back.
Audio is a particular pita, network too needs as close, and direct as possible connection to the CPU to get maximum performance.