There's plenty that can be done in traditional agriculture.
That the rich and naturally irrigated soils of the midwest and northeast are basically only used for animal feed agriculture now is a real shame from an economic diversification and health POV but also from an environmental perspective. Giant swathes of topsoil are depleted every year, and fertilizer and pesticide runoff pollutes entire drainage basins of these regions.
Cash crop agriculture like this is highly capital intensive, so squeezes out smaller operators, and does very little to support the surrounding towns.
Apple orchards in particular up until the 70s often used lead arsenate pesticide sprays. Yes, you read that right; lead and arsenic. Sprayed onto plants. It accumulated in the soil and basically never leaves, and is a serious potential health hazard.
There has been insufficient discussion of this, overall, and it's basically "buyer beware" for land.
As it stands today, as a nation, the United States supply of vegetables and many other products is totally dependent on the Colorado river. A variety of problems from climate change to terrorist or other attack could rapidly impact our ability to feed ourselves.