No reason Microsoft wouldn't port to a new ARM variant from e.g. nVidia, or some other RISC.
It also makes it easy to add specialized accelerators and processor instructions that you can then build support for in the operating system you ship.
There is no processor feature of a modern CPU that doesn't give advantage to all the operating systems that use it. VT-x virtualisation, AVX, AES-NI, ARM Neon: all are used by MacOS, Linux and Windows.
TEEs (SGX+MEE/TrustZone/SEV, Google Titan, Apple T2) serve similar purposes and have similar flaws (like permanent exploits) and trade-offs (same CPU -> side channels, uarch complexity problems, different CPU -> cost; separate chip -> heterogeneity, cost). It seems like the Titan/T2 approach leads to higher security, but I'm not sure that is settled yet. A new arch like RISC-V could do better (though it doesn't look like RISC-V will do that). I would love to see hardware support for micro/nano kernels, but that seems as far away as ever.
Obviously it is good to have a guaranteed client for your chips, but I can't see it stopping Intel if shoestring outfits can build something like RISC-V.
I think they profiled these operations easily and made sure that they were cheap to execute on their CPU but I'm not certain there's dedicated silicon for that.
It's probably easier to achieve that coordination when there's a vertical integrator who can strong-arm everyone to make that migration.