I'd personally be more concerned about stability and drop-out issues. Apple sells Rosetta as an "ahead-of-time" translator, but that is necessarily best effort (because true transpiling is not a solvable problem, e.g. self-modifying code). Thus, there is always the possibility that the JIT gets invoked in the middle of the audio processing thread, and that won't end well for real-time guarantees. There are also programs that just don't work under Rosetta properly (for unclear reasons).
Also, audio companies sometimes like to use "fun" DRM/copy protection systems.
Besides, audio apps themselves doing JIT would not be unheard of. For example, that'd be a very efficient way of implementing a modular synth. Those apps could JIT in a realtime-safe way; Rosetta can't (it doesn't have enough info).
You responded with some technically-detailed speculation, which, fair enough. I guess we'll have to wait and see.
Switching to x86 emulation for compatibility, will be a performance hit against running native ARM
The arguments in the thread about "but a lot of software right now runs in emulation" and "who knows when the software companies will get around to transitioning" aren't wrong, per se, but they're also arguments that long-time Apple users have heard variants of in the PowerPC to x86 transition. And in the (original) Mac OS to OS X transition. And in the 68K to PowerPC transition. It turns out that when transitioning your software to the new platform doubles your performance and/or is necessary to keep selling your product, you have a fairly strong motivation to do the work.