Re:Anti-diarrhoea drug drives cancer cells to cell death
by sm4rk0 on Wednesday December 23, 2020 @02:37PM
(#25521260)
> 1. Loperamide is not unique. I don't know why these researchers have singled it out.
From the paper:
> We previously screened a library containing autophagy-inducing compounds and identified the Food and Drug Administration-approved drug loperamide (LOP) as potent inducer of ACD in the glioblastoma multiforme (GBM) cell line MZ-54 [7]
7: Zielke S, Meyer N, Mari M, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994
From the paper:
> We previously screened a library containing autophagy-inducing compounds and identified the Food and Drug Administration-approved drug loperamide (LOP) as potent inducer of ACD in the glioblastoma multiforme (GBM) cell line MZ-54 [7]
7: Zielke S, Meyer N, Mari M, et al. Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells. Cell Death Dis. 2018;9:994