The first thing I'd miss is pockets. Working with your hands, e.g. conducting experiments, usually requires a number of items to be close at hand, and you can't put anything on a workbench at zero g.

The second thing is individual thermal comfort. Say, 20°C is usually "fine for everyone", but some people would feel that it's quite warm to wear a T-shirt, while other people would find it barely warm enough to not wear a coat.