You should give F# a try. Check out Feliz [0], it integrates flawlessly with React and you can use elmish for the internal state management of components. You can use F# on the backend as well (Giraffe, Saturn) and use Fable.Remoting for RPC.

[0] https://github.com/Zaid-Ajaj/Feliz [1] https://github.com/Zaid-Ajaj/Fable.Remoting