Not yet[1] likely to see WebCrypto first and/or something similar to Node's crypto library. You could probably get away with wasm build of a C/C++ or Rust library if you don't mind getting dirty.

1. https://github.com/denoland/deno/issues/1891

edit:

partial webcrypto/wasm option already available

https://deno.land/x/[email protected]